Bisphenol A detection based on nano gold-doped molecular imprinting electrochemical sensor with enhanced sensitivity.

A facile electrochemical sensor based on nano gold-doped molecularly imprinted polymer (MIP) was proposed to realize the selective detection of bisphenol A (BPA) with enhanced sensitivity. Initially, gold-doped MIP (Au@MIP) film was constructed by electropolymerizing p-aminobenzoic acid (PABA) and BPA with in situ gold reduction to distribute gold nanoparticles nearby the imprinted cavities. Subsequently, the template molecules were further extracted from the polymer film, then the MIP could rebind with the template molecules to achieve specific detection of BPA. The nano gold-doped MIP increased the effective surface area and promoted conductivity when BPA was oxidized in the imprinted cavities, which improved the determination sensitivity. Under optimal conditions, the prepared sensor displayed a linear range from 0.5 to 100 μM for BPA detection with a detection limit of 52 nM. The designed sensor was further used to detect BPA in food samples, obtaining satisfactory recoveries from 96.7% to 107.6%.