Expression of interferon-stimulated gene 20 (ISG20), an antiviral effector protein, in glomerular endothelial cells: possible involvement of ISG20 in lupus nephritis.

Renal failure(2023)

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摘要
In GECs, ISG20 was regulated TLR3 but not TLR4, TLR7, or TLR9 signaling. Moreover, ISG20 was involved in regulating CX3CL1 production. In addition to regulating antiviral innate immunity, ISG20 may act as a mediator of CX3CL1 production, thereby inducing glomerular inflammation, particularly in patients with LN.
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关键词
glomerular endothelial cells,antiviral effector protein,isg20,endothelial cells,interferon-stimulated
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