CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes.

Russell C Dale,Terrence Thomas,Shrujna Patel,Velda X Han,Kavitha Kothur,Christopher Troedson,Sachin Gupta,Deepak Gill,Stephen Malone,Michaela Waak,Sophie Calvert,Gopinath Subramanian,P Ian Andrews,Tejaswi Kandula,Manoj P Menezes,Simone Ardern-Holmes,Shekeeb Mohammad,Sushil Bandodkar,Jingya Yan

Annals of clinical and translational neurology（2023）

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摘要

CSF neopterin and quinolinic acid are neuroinflammatory and excitotoxic metabolites. This CSF metabolomic inflammatory panel can discriminate ITES from other causes of new onset seizures or status epilepticus, and rapid results (4 h) may facilitate early immune modulatory therapy.

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