Firefly luciferin methyl ester illuminates the activity of multiple serine hydrolases.

Innus Mohammad, Kate L Liebmann,Stephen C Miller

Chemical communications (Cambridge, England)（2023）

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摘要

Firefly luciferin methyl ester is hydrolyzed by monoacylglycerol lipase MAGL, amidase FAAH, poorly-characterized hydrolase ABHD11, and hydrolases known for -depalmitoylation (LYPLA1/2), not just esterase CES1. This enables activity-based bioluminescent assays for serine hydrolases and suggests that the 'esterase activity' responsible for hydrolyzing ester prodrugs is more diverse than previously supposed.

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multiple serine hydrolases

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