Abrine, an IDO1 inhibitor, suppresses the immune escape and enhances the immunotherapy of anti-PD-1 antibody in hepatocellular carcinoma.

Xiaowei Liang,Hongwei Gao, Jian Xiao,Shan Han,Jia He,Renyikun Yuan,Shilin Yang,Chun Yao

Frontiers in immunology（2023）

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摘要

Overall, this study reveals that Abrine as an IDO1 inhibitor has an inhibition effect on immune escape and has a synergistic effect with the anti-PD-1 antibody on the treatment of HCC.

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关键词

IDO1, Abrine, CD47, PD-L1, m(6)A RNA modification, immune escape, hepatocellular carcinoma

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