Investigation of the pathological effects of histones, DNA, and nucleosomes in a murine model of sepsis.

Sarah K Medeiros,Neha Sharma,Dhruva Dwivedi,Patricia C Liaw

Shock (Augusta, Ga.)（2023）

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摘要

Our studies suggest that DNA masks the harmful effects of histones in vitro and in vivo. Although administration of histones contributed to the pathogenesis of sepsis, administration of nucleosomes or DNA were not harmful in healthy or septic mice.

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sepsis,nucleosomes,histones,pathological effects,murine model

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