The prognostic and predictive roles of plasma C-reactive protein and PD-L1 in non-small cell lung cancer.

Saara Kuusisalo,Antti Tikkanen,Elisa Lappi-Blanco,Timo Väisänen,Aija Knuuttila,Satu Tiainen,Jarkko Ahvonen,Sanna Iivanainen,Jussi P Koivunen

Cancer medicine（2023）

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摘要

Adding plasma CRP levels to PD-L1 TPS significantly increased the predictive value of sole PD-L1. Furthermore, patients with high CRP beard little benefit from anti-PD-(L)1 therapies independent of PD-L1 score. The study highlights the combined evaluation of plasma CRP and PD-L1 TPS as a negative predictive marker for ICI therapies.

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关键词

CRP, ICI, NSCLC, PD-L1, predictive, prognostic

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