Management of transient bone osteoporosis: a systematic review

Introduction Transient bone osteoporosis (TBO) is characterized by persistent pain, loss of function, no history of trauma and magnetic resonance image (MRI) findings of bone marrow edema. Source of data PubMed, Google scholar, EMABSE and Web of Science were accessed in February 2023. No time constrains were used for the search. Areas of agreement TBO is rare and misunderstood, typically affecting women during the third trimester of pregnancy or middle-aged men, leading to functional disability for 4-8 weeks followed by self-resolution of the symptoms. Areas of controversy Given the limited evidence in the current literature, consensus on optimal management is lacking. Growing points This systematic review investigates current management of TBO. Areas timely for developing research A conservative approach leads to the resolution of symptoms and MRI findings at midterm follow-up. Administration of bisphosphonates might alleviate pain and accelerate both clinical and imaging recovery.