Tripterygium wilfordii derivative celastrol, a YAP inhibitor, has antifibrotic effects in systemic sclerosis.

Pratyusha Chitturi,Shiwen Xu,Bahja Ahmed Abdi,John Nguyen,David E Carter,Sartak Sinha,Rohit Arora,Jeff Biernaskie,Richard J Stratton,Andrew Leask

Annals of the rheumatic diseases（2023）

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摘要

Our data clarify niches within the skin activated in fibrosis and suggest that compounds, such as celastrol, that antagonise the YAP pathway may be potential treatments for SSc skin fibrosis.

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关键词

Scleroderma, Systemic, Fibroblasts, Arthritis, Experimental, Therapeutics

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