How does mitochondrial import machinery fine- tune mitophagy? Different paths and one destination
Trends in endocrinology and metabolism: TEM(2023)
Abstract
Given their polyvalent roles, an intrinsic challenge that mitochondria face is the continuous exposure to various stressors including mitochondrial import defects, which leads to their dysfunction. Recent work has unveiled a presequence translocase-associated import motor (PAM) complex-dependent quality control pathway whereby misfolded proteins mitigate mitochondrial protein import and subsequently elicit mitophagy without the loss of mitochondrial membrane potential.
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Key words
mitochondrial quality control,protein quality control,TOM complex,PINK1,mitochondrial import,mitophagy
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