RTN3 and RTN4: Architects of SARS-CoV-2 replication organelles.

The Journal of cell biology（2023）

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摘要

SARS-CoV-2 depends on host proteins for successful replication. In this issue, Williams et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202203060) report that the ER membrane-modulating proteins RTN3 and RTN4 are required for the formation of SARS-CoV-2 replication organelles via direct interaction with viral proteins NSP3 and NSP4.

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rtn4,sars-cov

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