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Leucocyte-derived micro-RNAs as candidate biomarkers in Brugada syndrome.

Christian Steinberg,Nathalie Gaudreault,Andreas I Papadakis,Cyndi Henry,Jean Champagne,François Philippon,Gilles O'Hara,Louis Blier,Benoit Plourde,Isabelle Nault,Karine Roy,Jean-François Sarrazin,Alan Spatz,Yohan Bossé

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology（2023）

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Abstract
Brugada patients display a distinct miRNA expression profile compared with unaffected control individuals. There is also evidence that certain miRNAs (miR-145-5p and miR-585-3p) are associated with the symptom status of Brugada patients. The results suggest the principal utility of leucocyte-derived miRNAs as prognostic biomarkers for Brugada syndrome.
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Key words
Brugada syndrome, MicroRNA, Biomarker, NanoString, Risk prediction, Leucocyte derived
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