How obesity affects the disposition of intravenous anesthetics.

Shinju Obara,Keisuke Yoshida,Satoki Inoue

Current opinion in anaesthesiology（2023）

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摘要

Pharmacokinetic simulations or TCI using pharmacokinetic models that account for the influence of obesity on a drug's disposition are essential to predict plasma/effect-site concentrations of intravenous anesthetics and understand the temporal profile of drug concentrations and effect in patients with obesity, particularly severe obesity.

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intravenous anesthetics,obesity

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