Tolypocaibols: Antibacterial Lipopeptaibols from a Tolypocladium sp. Endophyte of the Marine Macroalga Spongomorpha arcta .

Two new lipopeptaibols, tolypocaibols A () and B (), and the mixed NRPS-polyketide-shikimate natural product maximiscin [(/)-)] were isolated from a sp. fungal endophyte of the marine alga . Analysis of NMR and mass spectrometry data revealed the amino acid sequences of the lipopeptaibols, which both comprise 11 residues with a valinol C-terminus and a decanoyl acyl chain at the N-terminus. The configuration of the amino acids was determined by Marfey's analysis. Tolypocaibols A () and B () showed moderate, selective inhibition against Gram-positive and acid-fast bacterial strains, while maximiscin [(/)-)] showed moderate, broad-spectrum antibiotic activity.