Randomized controlled pilot trial of prazosin for prophylaxis of posttraumatic headaches in active-duty service members and veterans.

Cindy L Mayer, Paul J Savage,Conner K Engle, Soleil S Groh,Jane B Shofer, Ameryth M Hargrove, Tammy J Williams, Eileen L Poupore,Kimberly L Hart,Ronald G Riechers,Robert L Ruff,Elaine R Peskind,Murray A Raskind

Headache（2023）

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摘要

This pilot study provides a clinically meaningful efficacy signal for prazosin prophylaxis of posttraumatic headaches. A larger randomized controlled trial is needed to confirm and extend these promising results.

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关键词

mild traumatic brain injury, noradrenergic signaling, posttraumatic headache, prazosin

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