Deciphering the anti-renal fibrosis mechanism of triptolide in diabetic nephropathy by the integrative approach of network pharmacology and experimental verification.

Decai Fan, Zi Ying,Yang Ying,Qi Qian,Yuanyuan Li, Panjun Wang,Xiaofei An,Ming Yan

Journal of ethnopharmacology（2023）

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摘要

• TP inhibited ECM deposition and prevented the occurrence of renal fibrosis in diabetic nephropathy . • TP could alleviate renal fibrosis by regulating the GSK3β/Nrf2/HO-1 pathway. • TP could inhibit the overexpression of NOX4 and the ROS level, and ameliorate proteinuria in db/db mice.

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关键词

diabetic nephropathy,network pharmacology,triptolide,fibrosis,anti-renal

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