Clinical and preclinical evaluation of miR-144-5p as a key target for major depressive disorder.

Xiaodong Wu,Yulong Zhang,Ping Wang,Xiaohui Li,Zhen Song, Chuke Wei,Qing Zhang,Bei Luo,Zhichun Liu,Yingying Yang,Zhenhua Ren,Huanzhong Liu

CNS neuroscience & therapeutics（2023）

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Abstract

miR-144-5p plays a vital role in regulating neuronal abnormalities in depression. Our findings provide translational evidence that miR-144-5p is a new potential therapeutic target for MDD.

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Key words

depression, miR-144-5p, neuroinflammation, neuronal destruction

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