Conduction treatment of temporal lobe epilepsy in rats: the dose-effect relationship between current resistance and therapeutic effect.
Frontiers in neurology(2023)
Abstract
Current resistance affected seizure control and cognitive protection in rats with TLE treated by current conduction. The lower current resistance, the better seizure control and cognitive protection in rats with TLE treated by current conduction. Glu/GABA, IL-1β/IL-1R1, and HMGB1/TLR-4 may participate in the anti-seizure mechanism of current conduction treatment.
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Key words
temporal lobe epilepsy (TLE), current conduction, glutamate, interleukin 1 beta (IL-1 beta), high mobility group protein B1 (HMGB-1)
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