Muscle-derived stem cell exosomes with overexpressed miR-214 promote the regeneration and repair of rat sciatic nerve after crush injury to activate the JAK2/STAT3 pathway by targeting PTEN.

Xiangyu Zeng,Wei Bian,Ziwen Liu,Jianming Li,Shuai Ren,Jian Zhang,Haoran Zhang, Bu Tegeleqi,Guanyi He,Mingyan Guan, Zewei Gao,Chi Huang,Jianyu Liu

Frontiers in molecular neuroscience（2023）

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摘要

In summary, the MDSCs-derived exosomes with overexpressed miR-214 is involved in peripheral nerve regeneration and repair in rats after sciatic nerve crush injury to activate the JAK2/ STAT3 pathway by targeting PTEN.

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关键词

stem cell,sciatic nerve,jak2/stat3 pathway,regeneration,muscle-derived

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