Helicobacter pylori infection may influence prevalence and disease course in myelin oligodendrocyte glycoprotein antibody associated disorder (MOGAD) similar to MS but not AQP4-IgG associated NMOSD.

In developing countries infection may be a significant environmental factor related to autoimmune demyelinating CNS disease. Our preliminary data suggests that may exert a differential influence - a largely protective role for MS-MOGAD but not NMOSD and may influence disease onset and course. This differential response maybe related to immuno-pathological similarities between MOGAD and MS in contrast to NMOSD. Our study further underscores the role of as a surrogate marker for poor gut hygiene in childhood and its association with later onset of autoimmune diseases.