Simultaneous Nbs1 and p53 inactivation in neural progenitors triggers High-Grade Gliomas (HGG).

David E Reuss,Susanna M Downing,Cristel V Camacho,Yong-Dong Wang,Rosario M Piro,Christel Herold-Mende,Zhao-Qi Wang,Thomas G Hofmann,Felix Sahm,Andreas von Deimling,Peter J McKinnon,Pierre-Olivier Frappart

Neuropathology and applied neurobiology（2023）

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摘要

Our findings show that concomitant inactivation of Nbs1 and p53 in mice promotes HGG with RIG features. This model could be useful for preclinical studies to improve the prognosis of these deadly tumours, but it also highlights the singularity of NBS1 among the other DNA damage response proteins in the aetiology of brain tumours.

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neural progenitors,<i>p53</i>

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