Mediation Analysis to Untangle Opposing Associations of High-Dose Docosahexaenoic Acid With IQ and Bronchopulmonary Dysplasia in Children Born Preterm.

Thomas R Sullivan,Jacqueline F Gould,Jana M Bednarz,Andrew J McPhee,Robert Gibson,Peter J Anderson,Karen P Best,Mary Sharp,Jeanie L Y Cheong,Gillian F Opie,Javeed Travadi,Peter G Davis,Karen Simmer,Carmel T Collins,Lex W Doyle,Maria Makrides

JAMA network open（2023）

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摘要

This study found that associations of DHA with BPD and IQ were largely independent. This finding suggests that if clinicians supplement children born preterm with high-dose DHA, any resulting increase in BPD risk would not be associated with meaningful reductions in the IQ benefit.

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bronchopulmonary dysplasia,acid,high-dose

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