Human complement component C3 N-glycome changes in type 1 diabetes complications.

Dinko Šoić,Jerko Štambuk,Marko Tijardović,Toma Keser,Gordan Lauc,Tomislav Bulum,Marijana Vučić Lovrenčić,Sandra Vučković Rebrina,Martina Tomić,Mislav Novokmet,Lea Smirčić-Duvnjak,Olga Gornik

Frontiers in endocrinology（2023）

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摘要

This study empowered the role of C3 N-glycosylation in T1D, showing value in distinguishing subjects with different diabetic complications. Being independent of the disease duration, these changes may be associated with the disease onset, making C3 N-glycome a potential novel marker of the disease progression and severity.

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diabetes,complement,n-glycome

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