Interaction between Peripheral and Central immune markers in Clinical High Risk for Psychosis.

Kankana Nisha Aji,Sina Hafizi,Tania Da Silva,Michael Kiang,Pablo M Rusjan,Cynthia S Weickert,Romina Mizrahi

Brain, behavior, & immunity - health（2023）

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Abstract

•Serum IL-8 levels are elevated in individuals at CHR for psychosis.•Positive association between elevated IL-8 and prodromal general symptom severity.•Inflammatory clusters (IL-1β, IL-2, IFN-γ) are identified (entire cohort and CHR).•TSPO levels did not differ between inflammatory clusters (entire cohort or CHR).•CRP, IL-1β, TNF-α and IFN-γ levels are the independent predictors of brain TSPO.

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Key words

Clinical high -risk, Peripheral inflammation, Neuroinflammation, MRI, PET, TSPO

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