Risk Factors for Progression and Toxic Effects After Preoperative Stereotactic Radiosurgery for Patients With Resected Brain Metastases.

Roshan S Prabhu, Tobi Akinyelu,Zachary K Vaslow,Jennifer K Matsui, Neda Haghighi,Tu Dan,Mark V Mishra,Erin S Murphy, Susan Boyles,Haley K Perlow,Joshua D Palmer,Cristian Udovicich,Toral R Patel,Zabi Wardak,Graeme F Woodworth, Alexander Ksendzovsky,Kailin Yang,Samuel T Chao,Anthony L Asher,Stuart H Burri

JAMA oncology（2023）

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摘要

In this cohort study, the rates of cavity LR, ARE, and MD after preoperative SRS were found to be notably low. Several tumor and treatment factors were identified that are associated with risk of cavity LR, ARE, MD, and OS after treatment with preoperative SRS. A phase 3 randomized clinical trial of preoperative vs postoperative SRS (NRG BN012) has began enrolling (NCT05438212).

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