Exhaustion of CD8 + central memory responder T cell differentiation provokes non-melanoma skin cancer in elderly kidney transplant recipients.

Jonas Leonhard,Matthias Schaier,Florian Kälble,Martin Zeier,Andrea Steinborn

Frontiers in immunology（2023）

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摘要

In conclusion, we provide evidence that immunosuppressive therapy inhibits differentiation of CD8 Tregs more than that of CD8 Tresps, resulting in an exhausted Tresp profile, thus providing a possible therapeutic approach to improve poor cancer immunity in elderly KTR.

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关键词

kidney transplantation,non-melanoma skin cancer,immunosuppressive therapy,CD8+ T cell differentiation,CD8+ regulatory T cells,CD8+ responder T cells

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