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Chronic tianeptine induces tolerance in analgesia and hyperlocomotion via mu-opioid receptor activation in mice.

Florence Allain,Aliza T Ehrlich,Michael McNicholas,Florence Gross,Weiya Ma,Brigitte L Kieffer,Emmanuel Darcq

Frontiers in psychiatry（2023）

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Abstract
These findings suggest that tianeptine's opioid-like effects require MOR and that chronic use could lead to tolerance.
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Key words
chronic tianeptine,analgesia,receptor,tolerance,mu-opioid
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