High JAK2V617F variant allele frequency is associated with coronary artery but not aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms.

Camilla Nordheim Solli,Sandra Chamat-Hedemand,Hanne Elming,Anh Ngo,Lasse Kjaer,Vibe Skov,Anders Lindholm Sørensen,Christina Ellervik,Hans Hasselbalch,Niels Eske Bruun

European journal of haematology（2023）

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摘要

In patients with MPNs, there is a significant association between having a VAF in the upper quartile (>52%), and severe coronary atherosclerosis, defined as a CACS >400. The presence of AVC is not associated with VAF.

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aortic valve disease, atherosclerosis, coronary, essential, Janus kinase 2, multidetector computed tomography, myelofibrosis, myeloproliferative disorders, polycythemia vera, thrombocythemia

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