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Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis.

Zhaojie Meng,Shuya Zhang,Wei Li,Yunzhe Wang,Minjie Wang,Xin Liu,Cong-Lin Liu,Sha Liao,Tianxiao Liu,Chongzhe Yang,Jes S Lindholt,Lars M Rasmussen,Lasse M Obel,Jane Stubbe,Axel C Diederichsen,Yong Sun,Yabing Chen,Paul B Yu,Peter Libby,Guo-Ping Shi,Junli Guo

European heart journal（2023）

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Abstract
Eosinophils release cationic proteins that can promote SMC calcification and atherogenesis using the BMPR-1A/1B-Smad-1/5/8-Runx2 signalling pathway.
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Key words
Eosinophil, Eosinophil cationic protein, Bone morphogenetic protein receptors, Smooth muscle cell, Calcification
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