Characterization of white matter alterations using diffusion kurtosis imaging in patients with amyotrophic lateral sclerosis.

Tanushka Anand,Abdullah Ishaque,Daniel Ta,Muhammad Umer Khan,Komal Bharti,Andrew Wu,Dennell Krebs,Christian Beaulieu,Peter Seres,Sanjay Kalra

Brain and behavior（2023）

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摘要

DKI abnormalities in the CST and CC are present in patients with UMN dysfunction, potentially revealing complementary information to DTI regarding the pathology and microstructural alterations occurring in such patients. DKI shows promise as a potential in vivo biomarker for cerebral degeneration in amyotrophic lateral sclerosis.

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关键词

corpus callosum, corticospinal tract, diffusion kurtosis imaging, diffusion tensor imaging, upper motor neuron

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