Spinocerebellar Ataxia Type 1 Characteristics in Patient-Derived Fibroblast and iPSC-Derived Neuronal Cultures.

Ronald A M Buijsen,Michel Hu,Maria Sáez-González,Sofia Notopoulou,Eleni Mina, Winette Koning,Sarah L Gardiner,Linda M van der Graaf,Elena Daoutsali,Barry A Pepers,Hailiang Mei,Vera van Dis,Jean-Philippe Frimat,Arn M J M van den Maagdenberg,Spyros Petrakis,Willeke M C van Roon-Mom

Movement disorders : official journal of the Movement Disorder Society（2023）

引用 0|浏览13

暂无评分

摘要

Patient-derived cells recapitulate key pathological features of SCA1 pathogenesis providing a valuable tool for the identification of novel disease-specific processes. This model can be used for high throughput screenings to identify compounds, which may prevent or rescue neurodegeneration in this devastating disease. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

查看译文

关键词

bioenergetics, disease modelling, electrophysiology, human induced pluripotent stem cells, MEA, neurodegeneration, neuronal aggregates, neuronal morphology, RNA sequencing, spinocerebellar ataxia type 1

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要