Effects of multiple pro-inflammatory stimuli in utero on the ileum of extremely premature ovine fetuses.

Julia Heiter,Matthew W Kemp,Owen B Spiller,Dominique Singer,John P Newnham,Suhas G Kallapur,Alan H Jobe,Boris W Kramer

Frontiers in immunology（2023）

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摘要

After exposure to chorioamnionitis induced by and/or lipopolysaccharide, inflammatory responses as well as structural changes of the enteric nervous system were more pronounced the longer and the more frequent the exposure to pro-inflammatory stimuli before birth. These changes may cause functional effects of clinical importance.

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关键词

chorioamnionitis, enteric nervous system, preterm fetal ileum, intestinal inflammation, necrotizing enterocolitis

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