A Comparison of Podoplanin Expression in Oral Leukoplakia and Oral Squamous Cell Carcinoma: An Immunohistochemical Study.

Vaishnavi Srinivasan,Ndvn Shyam,G Kiran Kumar,Vaishali Narayen,Paremala Konda,Korra Swetha Rani

Cureus（2023）

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摘要

Upregulation of PDPN can be related to the malignant transformation of OLs and biological aggressiveness of OSCCs. The enhanced immunoexpression of PDPN signifies that this immunomarker can have a role in tumor cell differentiation and the neoplastic progression of OSCCs. Increased density of lymphatic vessels suggested an important role of lymphangiogenesis in tumor progression and also as a prognostic factor for lymph nodal metastasis.

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podoplanin, oral squamous cell carcinoma, oral potentially malignant disorders, oral leukoplakia, immunohistochemistry

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