Amonafide Induces HUVEC Senescence by Inhibiting Autophagy.
Discovery medicine(2023)
摘要
We first discovered that amonafide caused normal cellular senescence in our experiments. Amonafide-induced cellular aging by inhibiting autophagy and activating the mTOR pathway. The findings may offer new strategies for managing adverse reactions to amonafide.
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关键词
amonafide, senescence, mTOR, autophagy
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