Automated isocenter optimization approach for treatment planning for gyroscopic radiosurgery.

This study demonstrates the feasibility of an automatic isocenter selection by clustering in the treatment planning process with the ZAP-X system. Even in complex cases where the existing approaches fail to produce feasible plans, the clustering method generates plans that are comparable to those produced by expert selected isocenters. Therefore, our approach can help reduce the effort and time required for treatment planning in gyroscopic radiosurgery.