In Regard to Zeng et al.

We read the article titled “Dose-Escalated 2-Fraction Spine Stereotactic Body Radiation Therapy: 28 Gy Versus 24 Gy in 2 Daily Fractions” by Zeng et al 1 Zeng KL, Abugarib A, Soliman H, et al. Dose-escalated two-fraction spine stereotactic body radiotherapy: 28 Gy vs. 24 Gy in 2 daily fractions [e-pub ahead of print]. Int J Radiat Oncol Biol Phys. https://doi.org/10.1016/j.ijrobp.2022.09.076, accessed September 27, 2022. Google Scholar with great interest. In this retrospective nonrandomized study, a local control benefit was demonstrated with 28 Gy compared with 24 Gy without increasing the vertebral compression fracture after a median follow-up of 23.5 months. Yet, the study still has some points to be clarified.