Safety of medicines during breastfeeding - from case report to modeling : A contribution from the ConcePTION project.

Evelina Cardoso,Monia Guidi,Nina Nauwelaerts,Hedvig Nordeng,Marie Teil,Karel Allegaert,Anne Smits,Peggy Gandia,Andrea Edginton,Shinya Ito,Pieter Annaert,Alice Panchaud

Expert opinion on drug metabolism & toxicology（2023）

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摘要

PBPK and popPK modeling are promising approaches to fill the gap of knowledge in medicine safety in breastfeeding, as illustrated with our escitalopram example.

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关键词

Breastfeeding, Breastfed infants, Drug exposure, Human milk, Pharmacokinetics, Physiologically based pharmacokinetics

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