A novel experimental model to investigate fungal involvement shows expression of Dectin-1 in periapical lesion pathogenesis.

Arshad Hasan,Talat Roome,Mohsin Wahid,Shazia Akbar Ansari,Javeria Ali Khan,Amber Kiyani,Syeda Neha Jilani

Journal of oral rehabilitation（2023）

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摘要

Immune cells of inflamed periapical tissue expressed Dectin-1 receptor in response to the microbial challenge from infected root canals and showed positive correlation with TLR-2 and OPN suggesting a possible receptor collaboration mediated by OPN. The expression of OPN and TNF-α showed positive correlation in response to fungal antigen, indicating a possible relationship.

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关键词

animal model, apical periodontitis, Dectin-1, mouse, Osteopontin, toll-like receptor

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