Is methotrexate safe for men with an immune-mediated inflammatory disease and an active desire to become a father? Results of a prospective cohort study (iFAME-MTX).
Annals of the rheumatic diseases(2023)
Abstract
Treatment with MTX is not associated with testicular toxicity, consistent with the very low concentration of intracellular MTX-PG. Therefore, therapy with MTX can be safely started or continued in men and with a wish to become a father.
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Key words
methotrexate,inflammatory disease,immune-mediated,ifame-mtx
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