Is methotrexate safe for men with an immune-mediated inflammatory disease and an active desire to become a father? Results of a prospective cohort study (iFAME-MTX).

Luis Fernando Perez-Garcia,Esther Röder,Bouwe P Krijthe, Laura Jc Kranenburg-van Koppen, Roxanne van Adrichem, Els Zirkzee,Pieter H Griffioen,Kris Peeters,Marry Lin,Eduard A Struys,Gerrit Jansen, Martijn Ba van Doorn,Robert de Jonge,Gert R Dohle,Radboud Jem Dolhain

Annals of the rheumatic diseases（2023）

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Abstract

Treatment with MTX is not associated with testicular toxicity, consistent with the very low concentration of intracellular MTX-PG. Therefore, therapy with MTX can be safely started or continued in men and with a wish to become a father.

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Key words

methotrexate,inflammatory disease,immune-mediated,ifame-mtx

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