Low-Dose Trans-Resveratrol Ameliorates Diabetes-Induced Retinal Ganglion Cell Degeneration via TyrRS/c-Jun Pathway.

Ke Xiao,Xiao-Hong Ma,Zheng Zhong,Yin Zhao,Xu-Hui Chen,Xu-Fang Sun

Investigative ophthalmology & visual science（2023）

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摘要

Low-dose trans-RSV can ameliorate diabetes-induced RGC degeneration via the TyrRS/c-Jun pathway. It can promote TyrRS nuclear translocation and bind to c-Jun, downregulating c-Jun phosphorylation and downstream pro-apoptotic genes.

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关键词

pathway,low-dose,diabetes-induced,c-jun

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