Crosstalk between TLR8 and RIG-I-like receptors enhances antiviral immune responses.

Killian E Vlaming, Kelly van Wijnbergen,Tanja M Kaptein,Monique Nijhuis,Neeltje J Kootstra,Godelieve J de Bree,Teunis B Geijtenbeek

Frontiers in medicine（2023）

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摘要

Our data strongly suggest that TLR crosstalk with RLRs leads to strong antiviral immunity as shown by induction of IL-12 and type I IFN responses in contrast to TLRs alone. Thus, co-stimulation of TLRs and RLRs might be a powerful strategy to induce reactivation of latent reservoir as well as antiviral immunity that eliminates the reactivated cells.

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关键词

toll like 7, 8 receptors, RIG-I like receptors (RLRs), immune activation, antiviral responses, crosstalk

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