Effects of allium cepa on ovarian torsion-detorsion injury in a rat model
Turkish journal of obstetrics and gynecology(2023)
Abstract
Objective: Ischemia/reperfusion (I/R) damage following detorsion treatment, tissue fibrosis, and adhesions cause secondary tissue damage in the ovaries. Many studies have been evaluated to minimize antioxidant damage in ovarian reserve loss while minimizing I/R damage. However, no study observed long-term effects on the ovarian torsion model in rats. In this study, we evaluated the profibrotic effects of A. cepa on an ovarian torsion model on rats. Materials and Methods: Group I (n=7) rats were the sham group. Group II (n=7) rats were the torsion group and Group III (n=7) rats were the torsion + A. cepa group. To observe the long-term effects of allium cepa, rats were fed for 21 days. Cellular damage I/R is evaluated by histopathological damage score, and transforming growth factor-beta 1 (TGF-beta 1) and alpha-smooth muscle actin (alpha-SMA) is measured to analyze the profibrotic effect. Results: A. cepa altered cellular damage due to improvement in the histopathological damage score with A. cepa intake. However, the profibrotic mediators TGF-beta 1 and a-SMA are non- significantly changed by the A. cepa (p=0.477 and p=0.185 respectively). Conclusion: A. cepa is a potent protective on cellular tissue, minimizing I/R damage on ovarian tissue histologically. Our study implies that A. cepa does not affect fibrosis-related mediators in the rat ovary.
MoreTranslated text
Key words
Allium cepa,fibrosis,ovarian torsion,ischemia-reperfusion injury,TGF-131,alpha-SMA
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined