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Zebrafish Larvae as an in vivo Model for Antimicrobial Activity Tests against Intracellular Salmonella .

Patrick Hauswirth,Jonas Buck, Ramya Puligilla,Claudio Luca Alter,Sandro Sieber,Beatrice Claudi,Joseph Fanous,Dirk Bumann,Jörg Huwyler

Frontiers in bioscience (Landmark edition)（2023）

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Abstract
The zebrafish-larvae model enables testing of antimicrobials for efficacy against extra- and intracellular in a complex environment. This model thus might serve for antimicrobial lead optimization prior to using rodent models.
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Key words
Salmonella enterica, infections, macrophages, zebrafish larvae, antibiotic resistance, drug screening
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