A Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious Outcomes.

Nira Hernández-Martín,Francisca Gomez, Ágata Silván,Rubén Fernández de la Rosa,Mercedes Delgado,Pablo Bascuñana,Miguel Ángel Pozo,Luis García-García

Journal of integrative neuroscience（2023）

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摘要

Our results do not support an acute anticonvulsant effect of a single dose of FLU. Besides, FLU did not show short-term neuroprotective or anti-inflammatory effects in the rat lithium-pilocarpine model of SE. Moreover, at the dose administered, FLU resulted in deleterious effects.

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flufenamic acid,status epilepticus,lithium-pilocarpine

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