Prognostic value of von Willebrand factor levels in patients with metastatic melanoma treated by immune checkpoint inhibitors.

Julia-Christina Stadler,Laura Keller,Christian Mess,Alexander T Bauer,Julian Koett,Glenn Geidel,Isabel Heidrich,Sabine Vidal-Y-Sy,Antje Andreas, Carlotta Stramaglia,Mark Sementsov, Wiebcke Haberstroh,Benjamin Deitert,Inka Lilott Hoehne,Robin Reschke,Thomas Haalck,Klaus Pantel,Christoffer Gebhardt,Stefan W Schneider

Journal for immunotherapy of cancer（2023）

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摘要

In this prospective cohort, coagulatory parameters such as ADAMTS13 activity and D-dimers are associated with OS but baseline vWF:Ag levels appeared as the only parameter associated with response and OS to ICI. This highlights a potential role of vWF as a biomarker to monitor ICI response of patients with malignant melanoma.

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关键词

Melanoma, Immunotherapy, Translational Medical Research, Tumor Microenvironment

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