Elucidating the pharmacological effects of Compound Kushen injection on MYC-P15-CCND1 signaling pathway in nasopharyngeal carcinoma - An in vitro study.

Zhishan Wu,Chao Wu,Jian Shi,Zhihong Huang,Shan Lu,Yingying Tan,Rongli You,Lina Hai,Jiaqi Huang,Siyu Guo,Yifei Gao,Zhengsen Jin,Xiaoyu Tao,Leiming You,Jiarui Wu

Journal of ethnopharmacology（2023）

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摘要

The key pathway, cell cycle and the corresponding core targets MYC, CCND1, and P15 were obtained from network pharmacology, molecular docking, and proteomics. CKI could inhibit the proliferation, migration, and invasion of NPC cells, induce apoptosis of C666-1 cells. Especially CKI may arrest cell cycle G0/G1 phase through regulating targets MYC/P15/CCND1 of cell cycle pathway.

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关键词

Nasopharyngeal carcinoma,Compound Kushen injection,Network pharmacology,Molecular docking,Proteomics,Experimental evaluation

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