Neuroinflammation After COVID-19 With Persistent Depressive and Cognitive Symptoms.

Joeffre Braga,Mariel Lepra,Stephen J Kish,Pablo M Rusjan,Zahra Nasser,Natasha Verhoeff,Neil Vasdev,Michael Bagby,Isabelle Boileau,M Ishrat Husain,Nathan Kolla,Armando Garcia,Thomas Chao,Romina Mizrahi,Khunsa Faiz,Erica L Vieira,Jeffrey H Meyer

JAMA psychiatry（2023）

Cited 10|Views26

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Abstract

In this case-control study, TSPO VT was higher in patients with COVID-DC. Greater TSPO VT is evidence for an inflammatory change of elevated gliosis in the brain of an individual with COVID-DC. Gliosis may be consequent to inflammation, injury, or both, particularly in the ventral striatum and dorsal putamen, which may explain some persistent depressive and cognitive symptoms, including slowed motor speed, low motivation or energy, and anhedonia, after initially mild to moderate COVID-19 illness.

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