Expression of αA-crystallin (CRYAA) in vivo and in vitro models of age-related cataract and the effect of its silencing on HLEB3 cells.

Xiaoling Ma,Yi Nan, Can Huang, Xiangyang Li, Yifan Yang, Wenjie Jiang,Mengyi Ye, Qian Liu,Yang Niu,Ling Yuan

Aging（2023）

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摘要

Hydrogen peroxide can promote apoptosis and arrest the cell cycle in HLEB3 cells, and naphthalene can cause cataract formation and damage the structure of the lens in rabbits. Both ARC models can reduce the expression of CRYAA. The expression of CRYAA silencing increased apoptosis and autophagy in HLEB3 cells.

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关键词

cataract,a-crystallin,age-related

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