A gene risk score using missense variants in SLCO1B1 is associated with earlier onset statin intolerance.

Margherita Bigossi,Cyrielle Maroteau,Adem Y Dawed,Alasdair Taylor,Sundararajan Srinivasan,Alaa' Lufti Melhem,Ewan R Pearson,Roberto Pola,Colin N A Palmer,Moneeza K Siddiqui

European heart journal. Cardiovascular pharmacotherapy（2023）

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摘要

We provide evidence that a gene risk score based on four common SLCO1B1 variants provides an easily implemented genetic tool that is more reliable than the current recommended practice in estimating the risk and predicting early onset statin intolerance.

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关键词

Pharmacogenomics, SLCO1B1, Statins, Adverse drug reactions, Precision medicine, Musculoskeletal symptoms

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