Tumour stemness and poor clinical outcomes in haemochromatosis patients with hepatocellular carcinoma.

Daniel M Di Capua,William Shanahan,Michele Bourke,Navneet Ramlaul, Josh Appel, Aoife Canney,Neil G Docherty, Erinn McGrath, Eabha Ring,Fiona Jones, Marie Boyle,Janet McCormack,Tom Gallagher,Emir Hoti,Niamh Nolan,John D Ryan,Diarmaid D Houlihan,Aurelie Fabre

Journal of clinical pathology（2023）

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Abstract

This study demonstrates that the clinical course of patients with HFE-HCC is more aggressive and provides the first data indicating that their tumours have increased expression of progenitor markers. These findings suggest patients with HFE-HCC may need to be considered for transplant at an earlier stage.

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Key words

cancer stem cells, liver, iron

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